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ChemicalBook CAS DataBase List 4-Nitropicolinaldehyde
108338-19-8

4-Nitropicolinaldehyde synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 95 percent / H2SO4, fuming HNO3 / 2 h / 100 - 105 °C
2: 18 percent / Heating
3: 74 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature
4: 66 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature

References:

Ashimori;Ono;Uchida;Ohtaki;Fukaya;Watanabe;Yokoyama [Chemical and Pharmaceutical Bulletin,1990,vol. 38,# 9,p. 2446 - 2458]

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