4-N-HEXYLOXYBROMOBENZENE synthesis
- Product Name:4-N-HEXYLOXYBROMOBENZENE
- CAS Number:30752-19-3
- Molecular formula:C12H17BrO
- Molecular Weight:257.17
Yield:-
Reaction Conditions:
Stage #1:4-bromo-phenol with potassium carbonate in N,N-dimethyl-formamide at 70; for 0.5 h;
Stage #2:1-Iodohexane in N,N-dimethyl-formamide at 70;
Steps:
Synthesis of 4-Alkoxy-1-bromobenzene used for the synthesis of 7
General procedure: A mixture of 4-bromophenol (50 mmol),DMF(70ml) and potassium carbonate (100 mmol)was stirred at 70C for 0.5 h. To the suspension was added alkyl iodide (50 mmol) andthe mixture was stirred at 70C overnight. Water (200 ml) was added and the mixturewas extracted with hexane. The organic extracts were washed with brine (50 ml), 1NNaOH solution (50 ml) and water (100 ml), dried over MgSO4, and evaporated to give4-alkoxy-1-bromobenzene (> 90%).
References:
Uchida, Yoshiaki;Tamura, Rui;Suzuki, Katsuaki;Takahashi, Hiroki;Aoki, Yoshio;Nohira, Hiroyuki [Molecular Crystals and Liquid Crystals,2015,vol. 615,# 1,p. 89 - 106]
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