ChemicalBook CAS DataBase List 4-METHYL-BENZENESULFINAMIDE

4-METHYL-BENZENESULFINAMIDE synthesis

10synthesis methods

Product Name:4-METHYL-BENZENESULFINAMIDE
CAS Number:6873-55-8
Molecular formula:C7H9NOS
Molecular Weight:155.22

10439-23-3
22 suppliers
$56.54/50mgs:

6873-55-8
30 suppliers
$18.00/250mg

Yield:6873-55-8 78%

Reaction Conditions:

with ammonia in diethyl ether at 0; for 0.75 h;

Steps:

1.1 Step 1: Preparation of 4-methylbenzenesulfinamide
4-methylbenzene-1-sulfinic chloride (11 g, 63.0 mmol) was dissolved in ether (50 mL), it was cooled to 0 °C and ammonia gas was purged for 45 mm. Upon completion of starting material, reaction mixture was concentrated under reduced pressure. Then into it water was added, solid was filtered off and washed with water. The obtained solid was dried under reduced pressure in dessicator over P205 to yield 4-methylbenzenesulfinamide (7.6 g, 49.0mmol, 78 % yield)‘H NMR (400 MHz, CDC13): (5= 7.65 (d, 2H), 7.33 (d, 2H), 4.29 (s, 2H), 2.43 (s, 3H); MS(ESI): m/z (%) = 155.33 (100%) (M+H)

References:

CADILA HEALTHCARE LIMITED;SHARMA, Rajiv;IYER, Pravin;AGARWAL, Sameer WO2018/225018, 2018, A1 Location in patent:Page/Page column 16; 17

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824-79-3 Synthesis