4-METHYL-5-THIAZOLEACETIC ACID synthesis
- Product Name:4-METHYL-5-THIAZOLEACETIC ACID
- CAS Number:5255-33-4
- Molecular formula:C6H7NO2S
- Molecular Weight:157.19
137-00-8
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5255-33-4
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Yield:-
Reaction Conditions:
with ruthenium trichloride;sodium periodate in water;ethyl acetate;acetonitrile at 20; for 2 h;Reagent/catalyst;Temperature;Solvent;
Steps:
1-3 Example 3
Add 71.6g (0.5mol) of 4-methylthiazole-5-ethanol, 50mL of acetonitrile, 50mL of ethyl acetate, and 20mL of water into a three-necked flask.After fully stirring at room temperature, 1.04 g (0.005 mol) of ruthenium trichloride was added, 213.9 g (1 mol) of sodium periodate was added in batches, and the stirring was continued at room temperature for 2 hours after the addition.After the reaction, the reaction was quenched with saturated sodium sulfite solution, the insoluble matter was removed by filtration, and the pH of the system was adjusted to 23 with hydrochloric acid.Concentrate under negative pressure to distill off the solvent, add 300 mL of ethyl acetate, wash twice with 50 mL of water, and then wash once with saturated sodium chloride solution.Stand for separation and separate the organic phase under reduced pressure distillation to recover ethyl acetate, and 4-methylthiazole-5-acetic acid for use;
References:
CN112724101,2021,A Location in patent:Paragraph 0028; 0031-0033; 0036-0038; 0041-0043
406727-23-9
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5255-33-4
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