4-Methyl-3-(trifluoromethyl)aniline synthesis
- Product Name:4-Methyl-3-(trifluoromethyl)aniline
- CAS Number:65934-74-9
- Molecular formula:C8H8F3N
- Molecular Weight:175.15
89976-12-5
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65934-74-9
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Yield:65934-74-9 61%
Reaction Conditions:
with hydrogenchloride;iron in water at 100;Reagent/catalyst;Solvent;Temperature;
Steps:
3 Example 3:
Synthesis of 4-methyl-3-trifluoromethylaniline: 32 g of iron powder,0.8 ml of 36% concentrated hydrochloric acid,150 ml of water, warmed to 70 , constant temperature 0.5 hours.Begin with the dropwise addition of 40 grams of 4-nitro-2-trifluoromethyl toluene,After the addition is complete until the temperature drops, heated to an external temperature of 100 reflux, sampling,Spotting (developer: 1: 3 dichloromethane and petroleum ether) followed the reaction, After the reaction was completed, the water was distilled off to obtain 31 g of the product as an organic phase.The crude product was crystallized by the method of Example 1 to obtain 21 g of pale yellow liquid,Yield 61%, HPLC purity> 98%.
References:
CN106316864,2017,A Location in patent:Paragraph 0049; 0051-0054; 0056; 0058-0061; 0063; 0065-0068
90162-13-3
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65934-74-9
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447-61-0
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65934-74-9
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