4-METHYL-2-PHENYL-1,3-OXAZOLE-5-CARBOXYLIC ACID synthesis
- Product Name:4-METHYL-2-PHENYL-1,3-OXAZOLE-5-CARBOXYLIC ACID
- CAS Number:91137-55-2
- Molecular formula:C11H9NO3
- Molecular Weight:203.19
4620-52-4
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Yield:91137-55-2 72%
Reaction Conditions:
with lithium hydroxide monohydrate in tetrahydrofuran;methanol;water at 20; for 4 h;
Steps:
General synthetic procedure for target compounds 1-8
General procedure: To a solution of the obtained ethyl ester intermediate (1 equiv) in 2:3:1 THF/MeOH/H2O (18 ml) was added LiOH·H2O (1.5 equiv). After stirring at room temperature for 4 h, the volatiles were removed under reduced pressure. The residue was acidified with 1N hydrochloric acid solution, and then filtered and the filter cake was washed with 5 mL of water, dried in vacuum to afford a white powder. Recrystallization from 75% EtOH gave the desired compounds 1-8.
References:
Xu, Xue;Deng, Liming;Nie, Lu;Chen, Yueming;Liu, Yanzhi;Xie, Rongrong;Li, Zheng [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 4,p. 525 - 528] Location in patent:supporting information
4620-46-6
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98-80-6
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91137-55-2
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1556560-87-2
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953408-85-0
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91137-55-2
11 suppliers
$45.00/5mg