4-METHYL-2-NITROPHENYL ISOCYANATE synthesis
- Product Name:4-METHYL-2-NITROPHENYL ISOCYANATE
- CAS Number:57910-98-2
- Molecular formula:C8H6N2O3
- Molecular Weight:178.14
32315-10-9
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$10.00/1g
89-62-3
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$13.00/25g
57910-98-2
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$64.00/1g
Yield:-
Reaction Conditions:
in dichloromethane at 0; for 0.5 h;
Steps:
Synthesis of the compounds 2 and 4; general procedure
General procedure: Bis(trichloromethyl) carbonate (BTC) (5.0 mmol 1.48 g) was dissolved in DCM (30 mL). The aromatic primary aniline (10.0 mmol) in DCM (20 mL) was added dropwise to the above solution at 0 °C over 30 min. After the aryl primary aniline reacted completely (monitoredby GC), triethylamine (25.0 mmol, 2.53g) was added dropwise to the above mixture and stirred for 1-2 h at room temperature (monitored by TLC). The solid was obtained after distillation of DCM, washing by water (2×10 mL), and filtration.
References:
Zhou, Shuguang;Yao, Ting;Yi, Jicheng;Li, Dashuai;Xiong, Jing [Journal of Chemical Research,2013,vol. 37,# 5,p. 315 - 319]
