ChemicalBook CAS DataBase List 4-Methoxybenzylboronic acid pinacol ester

4-Methoxybenzylboronic acid pinacol ester synthesis

11synthesis methods

Product Name:4-Methoxybenzylboronic acid pinacol ester
CAS Number:475250-52-3
Molecular formula:C14H21BO3
Molecular Weight:248.13

824-94-2 Synthesis

824-94-2
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$24.19/5G

73183-34-3
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$6.00/5g

4-Methoxybenzylboronic acid pinacol ester

475250-52-3
58 suppliers
$22.00/250mg

Yield:475250-52-3 90%

Reaction Conditions:

with tris(2,4-pentanedionato)iron(III);magnesium in tetrahydrofuran at -10; for 8 h;Inert atmosphere;

Steps:

3

Example 3: Under the conditions of adding magnesium turnings in situ,The boron esterification of p-methoxybenzyl chloride with pinacol diboron catalyzed by Fe(acac)3 was carried out by adding the catalyst (3.5 mg, 0.010 mmol, 2 mol%) in order under argon protection.Bis(pinacolato)boronic acid ester (127.0 mg, 0.5 mmol),Magnesium turnings (16.8 mg, 0.7 mmol),Tetrahydrofuran (1 ml) with p-methoxybenzyl chloride added at -10°C183 μl, 1.35 mmol), the reaction was carried out for 8 hours, and the reaction was terminated with the addition of water.The ester was extracted and the yield calculated by gas chromatography was 90%.

References:

CN107903281,2018,A Location in patent:Paragraph 0022