4-METHOXYBENZOFURAN-2-CARBOXYLIC ACID synthesis
- Product Name:4-METHOXYBENZOFURAN-2-CARBOXYLIC ACID
- CAS Number:50551-59-2
- Molecular formula:C10H8O4
- Molecular Weight:192.17
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Yield:-
Reaction Conditions:
with sodium hydroxide;water in tetrahydrofuran;methanol; for 3 h;Heating / reflux;
Steps:
D.5
To a suspension of methyl 4-methoxy-benzofuran-2-ylcarboxylate (206 mg, 1.0 mmol) in THF/METHANOL/WATER (6 ml, 1/1/1) was added 2M aqueous NAOH (1.0 ml) and refluxed until saponification was completed (-3 h). The reaction mixture was acidified with 1M aqueous HCl (10 ml) and diluted with ethyl acetate (30 ml). The separated organic layer was washed with 1M aqueous HCl (30 ml), brine (30 ml), dried over sodium sulfate, and concentrated in vacuo to provide 4-METHOXY-BENZOFURAN-2-YLCARBOXYLIC acid as a white solid (189 mg, 0.96 mmol), which was used without further purification
References:
WO2005/19174,2005,A1 Location in patent:Page/Page column 45
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