4-Maleimidophenol synthesis
- Product Name:4-Maleimidophenol
- CAS Number:7300-91-6
- Molecular formula:C10H7NO3
- Molecular Weight:189.17
108-31-6
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Yield: 88.5%
Reaction Conditions:
Stage #1:maleic anhydride;4-amino-phenol in acetone at 20; for 1 h;
Stage #2: with sodium acetate;triethylamine;hydroquinone in toluene at 115; for 2.5 h;
Steps:
7 Synthesis of N-4- hydroxyphenyl maleimide
Maleic anhydride 0.6mmol weighed into three neck round bottom flask, dissolve with 5ml of acetone, the acetone-aminophenol 5ml of 0.9mmol dissolved by constant pressure funnel was slowly added dropwise three-necked flask, with magnetic stirring, at room temperature for 1h after the acetone solvent was removed by rotary evaporation, use 5ml of toluene as a solvent, 0.006g of anhydrous sodium acetate were added to the reaction system, 0.2ml of triethylamine, 0.012 g of hydroquinone, 115 deg.] C was slowly warmed to reflux for 2.5h during the reaction by thin layer chromatography silica gel plate track.After the reaction was cooled to room temperature, the solvent was removed by rotary evaporation, to obtain a concentrate, the concentrate was subjected to silica gel column chromatography (eluent: VPetroleum ether: VEthyl acetate= 12: 1), and collecting the target fluid, the rotation solvent in vacuo to give the desired product.Yield 88.5%.
References:
Zhejiang University of Technology;Chen Xiaolong;Lu Yuele;Fan Yongxian;Li Yanjuan;Shen Yinchu CN107162950, 2017, A Location in patent:Paragraph 0055-0057
![[4-(2,5-dioxopyrrol-1-yl)phenyl] acetate](/CAS/GIF/6637-46-3.gif)
6637-46-3
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7300-91-6
148 suppliers
$3.00/1g
123-30-8
613 suppliers
$10.00/5g
7300-91-6
148 suppliers
$3.00/1g