ChemicalBook CAS DataBase List 4-Isopropylphenyl isocyanate

4-Isopropylphenyl isocyanate synthesis

4synthesis methods

Product Name:4-Isopropylphenyl isocyanate
CAS Number:31027-31-3
Molecular formula:C10H11NO
Molecular Weight:161.2

98-82-8
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32315-10-9 Synthesis

32315-10-9
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31027-31-3
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$15.00/1g

Yield:-

Reaction Conditions:

with triethylamine in 1,2-dichloro-ethane at 0 - 85; for 8.5 h;Inert atmosphere;

Steps:

Method (i):
General procedure: A solution of an aromatic amine (9-41, 1.0 equiv) in DCE was added dropwise to a solution of triphosgene (1.0 equiv) in DCE was stirred under nitrogen at 0 °C. Then, Et₃N (1.0 equiv) in DCE was added dropwise to the mixture. The reaction mixture was stirred for 0.5 h at room temperature and for another 8 h at 85 °C. After completion, the solvent was evaporated under reduced pressure to obtain the corresponding substituted aromatic isocyanates without further purification

References:

Ruan, Banfeng;Zhang, Yuezhou;Tadesse, Solomon;Preston, Sarah;Taki, Aya C.;Jabbar, Abdul;Hofmann, Andreas;Jiao, Yaqing;Garcia-Bustos, Jose;Harjani, Jitendra;Le, Thuy Giang;Varghese, Swapna;Teguh, Silvia;Xie, Yiyue;Odiba, Jephthah;Hu, Min;Gasser, Robin B.;Baell, Jonathan [European Journal of Medicinal Chemistry,2020,vol. 190,art. no. 112100] Location in patent:supporting information

32315-10-9 Synthesis

32315-10-9
416 suppliers
$10.00/1g