ChemicalBook CAS DataBase List 4-Iodo-1-methyl-1H-imidazole

4-Iodo-1-methyl-1H-imidazole synthesis

4synthesis methods

Product Name:4-Iodo-1-methyl-1H-imidazole
CAS Number:71759-87-0
Molecular formula:C4H5IN2
Molecular Weight:208

37067-96-2 Synthesis

37067-96-2
59 suppliers
$53.02/1gm:

71759-87-0
191 suppliers
$53.00/1 g

Yield:71759-87-0 94%

Reaction Conditions:

with ethylmagnesium bromide in diethyl ether;dichloromethane at 20; for 0.333333 h;

Steps:

4.1. 4-Iodo-1-methyl-1H-imidazole (15)
EtMgBr (3.0 M solution in ether, 11.00 mL, 32.9 mmol) wasadded to a solution of 14 (10.00 g, 29.9 mmol) in dry CH₂Cl₂(150 mL) at rt. over 15 min. The resulting mixture was stirredfor 20 min and water (20 mL) was added to the reaction mixtureafter running a TLC experiment to confirm all the starting materialis consumed. Then, the layers were separated. The aqueous layerwas extracted with CH₂Cl₂ (3 50 mL) and the combined organiclayers were dried (Na₂SO₄) and concentrated to isolate 15 as paleyellow oil (5.86 g, 94%).

References:

Koswatta, Panduka B.;Kasiri, Sabha;Das, Jayanta K.;Bhan, Arunoday;Lima, Heather M.;Garcia-Barboza, Beatriz;Khatibi, Nicole N.;Yousufuddin, Muhammed;Mandal, Subhrangsu S.;Lovely, Carl J. [Bioorganic and Medicinal Chemistry,2017,vol. 25,# 5,p. 1608 - 1621]

FullText

71759-89-2 Synthesis