ChemicalBook CAS DataBase List 4-Hydroxypyridine

4-Hydroxypyridine synthesis

7synthesis methods

Product Name:4-Hydroxypyridine
CAS Number:626-64-2
Molecular formula:C5H5NO
Molecular Weight:95.1

1692-15-5 Synthesis

1692-15-5
450 suppliers
$6.00/1g

626-64-2
515 suppliers
$6.00/5g

Yield:626-64-2 76%

Reaction Conditions:

with copper(ll) sulfate pentahydrate;ellagic acid in methanol at 60; under 760.051 Torr; for 8 h;Green chemistry;

Steps:

In situ synthesis of Cu NPs-EA composite:
General procedure: In a typical reaction, 10 mol% CuSO4·5H2O, (0.049 g, 0.2 mmol)and 6.7 mol% EA (20 mg) were mixed in methanol followed by2 mmol of phenylboronic acid. This reaction mixture was kept ina preheated oil bath by maintaining the temperature at 60 °C andstirred under atmospheric pressure. After completion of the reac-tion, modified by TLC, the mixture was washed twice with hot ethylacetate to remove the reactant and product. The hot ethyl acetatewas removed from the reaction mixture and the resulting crudeproduct was purified by a column chromatography using silicagel 260 mesh (pet ether:ethyl acetate) ratio (25:75). The recov-ered catalyst was reused for the next run. All the products werecharacterized by1H and13C NMR spectra.

References:

Affrose, Abdullah;Azath, Ismail Abulkalam;Dhakshinamoorthy, Amarajothi;Pitchumani, Kasi [Journal of Molecular Catalysis A: Chemical,2014,vol. 395,p. 500 - 505]

FullText

620-08-6 Synthesis