Yield:-

Reaction Conditions:

with palladium 10% on activated carbon in decalin; for 20 h;Inert atmosphere;Reflux;

Steps:

5.2

Step 2: The mixture of S5-1 (20 g, 111 mmol), dodecene (30 mL) and 10% palladium on carbon (10 g, added portionly) were heated in decalin (180 mL) under reflux in a nitrogen atmosphere for 20 hrs. When the mixture had been cooled to 80 °C, ethanol (300 mL) was added and thecooled mixture was filtered under nitrogen, and washed with ethanol. The filtrate was evaporatedand the resulting slurry was cooled to 5 °C. Filtration was followed by washing with petroleumether and air drying gave S5-2. ‘H NMR (300 MHz, CDC13) ? 8.602 (s, 1H), 7.280-7.226 (m,1H), 7.133-7. 105 (d, J= 8.4Hz, 1H), 6.699-6.673 (d, J= 7.8Hz, 1H); LC-MS (ESI): 177 [MH].

References:

WO2015/95261,2015,A1 Location in patent:Page/Page column 46