4-Hydroxy -6-iodoquinoline-3- carbonitrile synthesis
- Product Name:4-Hydroxy -6-iodoquinoline-3- carbonitrile
- CAS Number:872576-92-6
- Molecular formula:C10H5IN2O
- Molecular Weight:296.06
![2-Propenoic acid, 2-cyano-3-[(4-iodophenyl)amino]-, ethyl ester](/CAS/20210111/GIF/709637-42-3.gif)
709637-42-3
3 suppliers
inquiry
872576-92-6
8 suppliers
inquiry
Yield:872576-92-6 85%
Reaction Conditions:
in diphenylether at 260; for 12 h;
Steps:
14.b
b) Preparation of 6-iodo-4-oxo-1,4-dihydro-quinoline-3-carbonitrile A mixture of (Z)-2-cyano-3-(4-iodo-phenylamino)-acrylic acid ethyl ester and (E)-2-cyano-3-(4-iodo-phenylamino)-acrylic acid ethyl ester (example 14a, 150 g, 0.44 mol) in diphenylether (1500 mL) was refluxed at 260° C. for 12 h. After cooling, ether was added. The solid was collected by filtration, washed with ether and dried to obtain 6-iodo-4-oxo-1,4-dihydro-quinoline-3-carbonitrile (110.5 g, 85%) as a black solid. LC-MS m/e 297 (MH+).
References:
US2006/4046,2006,A1 Location in patent:Page/Page column 20
1345447-16-6
0 suppliers
inquiry
872576-92-6
8 suppliers
inquiry
540-37-4
445 suppliers
$6.00/5g
872576-92-6
8 suppliers
inquiry