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ChemicalBook CAS DataBase List 4'-Hydroxy-4-biphenylcarbonitrile
19812-93-2

4'-Hydroxy-4-biphenylcarbonitrile synthesis

12synthesis methods
-

Yield:19812-93-2 89.2%

Reaction Conditions:

with sodium hydroxide in ethanol at 70 - 80; for 1 h;

Steps:

5

4-Cyano-4'-acetic acid biphenyl (6.5g, 0.027mol) and sodium hydroxide solution (1N, 55ml) and 13ml of ethanol were added to a 200ml three-necked flask at room temperature, and heated to 70 ° C ~ 80 ° C reaction 1h, TLC detected no raw material points. The reaction solution was cooled to 0 ° C, hydrochloric acid (5%) was added dropwise, the pH of the system was adjusted to 5-6, the yellow solid was precipitated, stirred for 30 min, filtered, and washed with water until neutral, to obtain a yellowish solid, dried. 30 ml of ethyl acetate was dissolved at room temperature, 0.5 g of activated carbon was added, and the mixture was heated to 50 ° C for 1 hour, and the activated carbon was filtered, and the filtrate was passed through a column (silica gel 5 g), and concentrated to dryness to give a white solid 4.7 g (yield: 89.2%).

References:

CN107619381,2018,A Location in patent:Paragraph 0007; 0029

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