ChemicalBook CAS DataBase List 4-FLUORO-3-METHOXYBENZOIC ACID

4-FLUORO-3-METHOXYBENZOIC ACID synthesis

5synthesis methods

Product Name:4-FLUORO-3-METHOXYBENZOIC ACID
CAS Number:82846-18-2
Molecular formula:C8H7FO3
Molecular Weight:170.14

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82846-18-2
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Yield: 97%

Reaction Conditions:

with water;sodium hydroxide in methanol at 20; for 4 h;

Steps:

79.2 Step 2: 4-fluoro-3-methoxybenzoic acid
A solution of methyl 4-fluoro-3-methoxybenzoate (11 g, 59.8 mmol) in methanol (100 mL) was treated with sodium hydroxide (9.5 g, 240 mmol) in water (20 mL) for 4h at room temperature. The solvent was removed in vacuo to afford a residue, which was dissolved in water (100 mL) and the pH value was adjusted to 4 with HC1 (IN). The solids were collected by filtration, washed with water (3 x 50 mL) and dried to afford 4-fluoro-3-methoxybenzoic acid as a white solid (9 g, 97 %). *H-NMR (300 MHz, DMSO) δ 7.66-7.55(m, 2H), 7.37-7.30(m, 1H), 3.91(s, 3H)

References:

BIOENERGENIX;MCCALL, John;KELLY, Robert, C.;ROMERO, Donna, L. WO2014/66795, 2014, A1 Location in patent:Paragraph 0175