4-ETHYNYL-BENZOIC ACID synthesis
- Product Name:4-ETHYNYL-BENZOIC ACID
- CAS Number:10602-00-3
- Molecular formula:C9H6O2
- Molecular Weight:146.14
3034-86-4
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$6.00/100mg
10602-00-3
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$10.00/250mg
Yield:10602-00-3 77%
Reaction Conditions:
with lithium hydroxide in methanol;water for 2 h;
Steps:
21 Synthesis of Compound B 11
To a solution of 2 ( 0.5 g, 3.13 mmol) in MeOH (10 ml) was added LiOH (0.312 g. 12.52mmol) in water (10 ml). The mixture was stirred for 2 h then quenched by HCI solution (2N) extracted with EtOAc (30 ml x 3). The combined organic was dried over anhydrous Na2SO4 concentrated to give the desired intermediate 3 (0.35 g, 77%) as yellow solid.
References:
HANGZHOU ZYLOX PHARMA CO., LTD.;WANG, Bing;ZHAO, Jonathon Zhong WO2014/82286, 2014, A1 Location in patent:Paragraph 67
75867-41-3
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10602-00-3
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150969-54-3
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10602-00-3
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33577-98-9
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10602-00-3
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16116-80-6
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$80.00/1g
10602-00-3
205 suppliers
$10.00/250mg