4'-DIMETHYLAMINOACETOPHENONE synthesis

14synthesis methods

Product Name:4'-DIMETHYLAMINOACETOPHENONE
CAS Number:2124-31-4
Molecular formula:C10H13NO
Molecular Weight:163.22

4-(Dimethylamino)-a-methyl-benzenemethanol

5338-94-3
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2124-31-4
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$5.00/1g

Yield:2124-31-4 97%

Reaction Conditions:

with [Cu₆(SC₅H₄N)6];potassium hydroxide in toluene at 70; for 24 h;Glovebox;Inert atmosphere;

Steps:

6 Example 6: [Cu6 (pyt) 6]Catalytic Dehydrogenation of Dimethylamino-1-phenylethanol

In the glove box, will be to dimethylamino -1 - phenethyl alcohol (1.0 mmol), [Cu₆ (Pyt)₆ ] (0.1 mmol), KOH (1.0 mmol) is added to the test tube with the magnetic coil in the has, then adding 2.0 ml dry toluene solvent. After the sealed reaction tube, is taken out of the glove box. Toward the nozzle leads into the small and stable and low production, stable air flow after such as, for 70 °C reaction under 24 h; after the reaction, extracted with ethyl acetate (3 × 5 ml), the combined organic phase, dried with anhydrous sodium sulfate, filtered, concentrated filtrate for rotary evaporator, and then separating and purifying column law silica gel chromatography, to obtain the target product to dimethylamino acetophenone (yield 97%).

References:

CN106588957,2017,A Location in patent:Paragraph 0027

50-00-0 Synthesis