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ChemicalBook CAS DataBase List 4-CYANO-2-FLUORO-BIPHENYL
93129-69-2

4-CYANO-2-FLUORO-BIPHENYL synthesis

4synthesis methods
-

Yield:93129-69-2 81%

Reaction Conditions:

Stage #1: 1-bromo-3-fluoro-4-phenylbenzenewith magnesium;lithium chloride in tetrahydrofuran at 20;Inert atmosphere;
Stage #2: N-cyano-N-phenyl-p-toluenesulfonamide in tetrahydrofuran at 0 - 20;Inert atmosphere;

References:

Anbarasan, Pazhamalai;Neumann, Helfried;Beller, Matthias [Chemistry - A European Journal,2011,vol. 17,# 15,p. 4217 - 4222] Location in patent:supporting information; experimental part

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