4-CHLOROMETHYL-2-METHYLTHIAZOLE HYDROCHLORIDE synthesis
- Product Name:4-CHLOROMETHYL-2-METHYLTHIAZOLE HYDROCHLORIDE
- CAS Number:77470-53-2
- Molecular formula:C5H7Cl2NS
- Molecular Weight:184.09
21262-97-5
1 suppliers
inquiry
77470-53-2
85 suppliers
$19.00/1g
Yield: 93%
Reaction Conditions:
with thionyl chloride in 1,2-dichloro-ethane at 30 - 70; for 0.5 h;
Steps:
Thionyl chloride (13.1 g, 0.11 mol) in dichloroethane (60 mL) was added to an intensively stirred solution of 4-(chloromethyl)-4,5-dihydro-2-methyl-4-thiazolol in dichloroethane (Description 81), maintaining the reaction temperature below 30 0C. The mixture was stirred at 65-70 0C for 30 min, cooled and the solvent was evaporated under reduced pressure. The residue was crystallized from EtOAc to give the title compound as a crystalline solid (17.12 g, 93%).
References:
Merck Sharp & Dohme Limited;DIRAT, Olivier;ELLIOTT, Jason, Matthew WO2007/3965, 2007, A1 Location in patent:Page/Page column 37
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
77470-53-2
85 suppliers
$19.00/1g
