4-Chloro-6-fluoroquinoline synthesis
- Product Name:4-Chloro-6-fluoroquinoline
- CAS Number:391-77-5
- Molecular formula:C9H5ClFN
- Molecular Weight:181.59
38470-26-7
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391-77-5
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Yield:391-77-5 85%
Reaction Conditions:
with manganese(IV) oxide;iodine;trichlorophosphate in 1,2-dichloro-ethane at 50; for 2 h;Reagent/catalyst;
Steps:
6 Example 6
This example is a process for the preparation of 4-chloro-6-fluoroquinoline.
A four-necked flask was charged with 412.55 mL of phosphorus oxychloride,11.5 g of iodine and 165.0 g of manganese dioxide,Heated to 50 ° C with stirring,660 mL of a dichloroethane solution containing 165.02 g of 6-fluoro-2,3-dihydroquinolin-4 (1H) -one prepared in Example 4 was added dropwise,Reflux reaction 2h,The dichloroethane was then removed in vacuo,The residue was neutralized with cold aqueous sodium bicarbonate to a pH of 5 to 6, filtered and the filter cake was washed with water to neutral,Dried in vacuo to give 154.22 g of a pale gray solid 4-chloro-6-fluoroquinoline in a yield of 85.0%.
References:
CN106565602,2017,A Location in patent:Paragraph 0008; 0024; 0025; 0026; 0027
391-78-6
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391-77-5
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391-77-5
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318-35-4
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391-77-5
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391-77-5
234 suppliers
$5.00/250mg