ChemicalBook CAS DataBase List 4-Chloro-3-nitrotoluene

4-Chloro-3-nitrotoluene synthesis

13synthesis methods

Product Name:4-Chloro-3-nitrotoluene
CAS Number:89-60-1
Molecular formula:C7H6ClNO2
Molecular Weight:171.58

27329-27-7 Synthesis

27329-27-7
99 suppliers
$7.00/250mg

89-60-1
192 suppliers
$6.00/5g

Yield: 51%

Reaction Conditions:

with 2.9-dimethyl-1,10-phenanthroline;oxygen;copper (I) acetate;silver sulfate;sodium chloride in dimethyl sulfoxide at 160; for 24 h;Schlenk technique;

Steps:

20 Example 20. Synthesis of 2-nitro-4-methyl chlorobenzene.
Silak reaction tube equipped with a magnetic stirrer was charged with 6.2 mg of silver sulfate,36.3 mg of copper acetate, 12.5 mg of 2,9-dimethyl-1,10-o-phenanthroline,36.2 mg of 2-nitro-4-methylbenzoic acid and 17.5 mg of sodium chloride4 mL of dimethyl sulfoxide.The reaction was heated at 160 ° C for 24 hours in the presence of oxygen.After the reaction was completed, distilled water was added to quench the reaction,Extraction with ethyl acetate 3 times, each time 10mL,The combined organic phases are concentrated,17.5 mg of 2-nitro-4-methylchlorobenzene was obtained,The yield is 51%.

References:

Nanchang University;Fu Zhengjiang;Cai Hu;Li Zhaojie;Jiang Ligao CN107325002, 2017, A Location in patent:Paragraph 0091

89-62-3 Synthesis