ChemicalBook CAS DataBase List 4-chloro-2-isopropylphenol

4-chloro-2-isopropylphenol synthesis

4synthesis methods

Product Name:4-chloro-2-isopropylphenol
CAS Number:54461-05-1
Molecular formula:C9H11ClO
Molecular Weight:170.64

88-69-7 Synthesis

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Yield:54461-05-1 1.29 g

Reaction Conditions:

with 2-aminopyridine;sulfuryl dichloride in toluene at 65; for 23 h;

Steps:

1.a 4-chloro-2-isopropyl-phenol

2-Isopropylphenol (1.36 g), 2-aminopyridine (75 mg, 0.08 equivalents), and sulfuryl chloride (803 μL, 1.0 equivalent) were dissolved in toluene (20 mL), and the resulting mixture was stirred in an oil bath at 65°C for 23 hours. Water was added to the reaction mixture, the product was extracted with ethyl acetate, the organic layer was dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to obtain a crude product. The obtained crude product was purified by silica gel column chromatography (developing solvent, ethyl acetate:hexane =1:15) to obtain 1.29 g of the title compound.

References:

KR2016/30503,2016,A Location in patent:Paragraph 0511; 0513; 0514

51241-43-1 Synthesis