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508203-26-7

4-chloro-2,5-difluorobenzamide synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: thionyl chloride / N,N-dimethyl-formamide / 80 °C
2: ammonium hydroxide / chloroform / 5 °C

References:

Negoro, Kenji;Yonetoku, Yasuhiro;Misawa-Mukai, Hana;Hamaguchi, Wataru;Maruyama, Tatsuya;Yoshida, Shigeru;Takeuchi, Makoto;Ohta, Mitsuaki [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 17,p. 5235 - 5246]