ChemicalBook CAS DataBase List (4-CARBOXYPHENYL)THIOUREA

(4-CARBOXYPHENYL)THIOUREA synthesis

4synthesis methods

Product Name:(4-CARBOXYPHENYL)THIOUREA
CAS Number:7366-56-5
Molecular formula:C8H8N2O2S
Molecular Weight:196.23

4-[[(Benzoylamino)thioxomethyl]amino]benzoic acid

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Yield:7366-56-5 93%

Reaction Conditions:

with water;sodium hydroxide for 0.5 h;Reflux;

Steps:

4-thioureidobenzoic acid (8)
A mixture of 4-(3-benzoylthioureido)benzoic acid (7) (10.0 mmol) and 10% sodium hydroxide (10.0 mmol) in water (20 mL) was heated under reflux for 30 min. The reaction mixture was cooled and neutralized by HCl. The formed product was filtered off, washed with water, driedand crystallized from butanol to give a white powder in 93% yield. mp > 300 C;mmax (KBr) 3440, 3339, 3279, 3170, 1684, 1291 cm-1; dH (300 MHz, DMSO-d6) 12.72 (1H, br s, COOH), 9.96 (1H, s, NH), 7.54-7.90 (4H, m, ArH’s), 3.37 (1H, s, NH2); m/z (EI, 70 eV) 196(10), 179(98), 162(98), 134(75), 120(95), 92(35); Elem.Anal. Calcd for C8H8N2O2S (196.23): C, 48.97; H, 4.11; N, 14.28. Found: C, 48.84;H, 4.07; N, 14.24.

References:

Haggam, Reda A.;Assy, Mohamed G.;Sherif, Mohamed H.;Galahom, Mohamed M. [Research on Chemical Intermediates,2017,vol. 43,# 11,p. 6299 - 6315]

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