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53257-32-2

4-(BROMOMETHYL)-3,5-DIMETHYLISOXAZOLE synthesis

2synthesis methods
-

Yield:-

Reaction Conditions:

with phosphorus tribromide in dichloromethane at 20; for 3 h;

Steps:

48

To a solution of (3,5-dimethyl-l,2-oxazol-4-yl)methanol (805 mg, 6.3 mmol) in anhydrous dichloromethane (60 mL) was added dropwise phosphorus tribromide (1.2 mL, 12.6 mmol). The mixture was stirred at room temperature for 3 hours.Dichloromethane was evaporated, and the residue was dried in vacuo, affording 4- (bromomethyl)-3,5-dimethyl-l,2-oxazole. The product was used without further purification.

References:

WO2010/132999,2010,A1 Location in patent:Page/Page column 109

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