ChemicalBook CAS DataBase List 4-Bromo-N-propylbenzamide

4-Bromo-N-propylbenzamide synthesis

6synthesis methods

Product Name:4-Bromo-N-propylbenzamide
CAS Number:223557-19-5
Molecular formula:C10H12BrNO
Molecular Weight:242.11

39887-27-9
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223557-19-5
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$46.00/1g

Yield:223557-19-5 98%

Reaction Conditions:

with aluminum (III) chloride;manganese;cobalt(II) diacetate tetrahydrate;isopropyl alcohol at 22;Reagent/catalyst;

Steps:

Olefin Hydrogenation. General procedure with AlCl_3.

General procedure: General procedure with AlCl₃: This reaction may be carried out under ambient temperature and atmosphere. The olefin (0.2 mmol) (if solid), Mn powder (33 mg, 0.3 mmol), Co(OAc)₂?4H₂O (14.2 mg, 30 mol%) and AlCl₃ (26.6 mg, 0.2 mmol) are weighed out and added to a 5 mL one-dram vial equipped with a stirring bar. A cap is placed on the reaction vessel and i-PrOH (2 mL) is added. The reaction is stirred vigorously for 4-20 h at rt. The reaction initially turns blue and over time turns black. The mixture is diluted with CH₂Cl₂, poured into a separating funnel and quenched with saturated aqueous NaHCO₃ solution. After phase separation the aqueous phase is extracted twice further with CH₂Cl₂. The combined organic phases are washed with brine, dried over MgSO₄ and filtered through a short plug of silica gel. The solvent is removed in vacuo to furnish the hydrogenated product without the need for further purification.