4'-Bromo-2-nitro-biphenyl synthesis
- Product Name:4'-Bromo-2-nitro-biphenyl
- CAS Number:70873-41-5
- Molecular formula:C12H8BrNO2
- Molecular Weight:278.1
Yield:70873-41-5 92%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);sodium carbonate in ethanol;water;toluene; for 24 h;Reflux;
Steps:
7 Preparation of compound C-7-1
After adding 1,4-dibromo-2-nitrobenzene (50 g, 177.99 mmol), phenyl boronic acid (19.7 g, 161.81 mmol), Na2CO3 (51 g, 485.43 mmol), and Pd(PPh3)4 (9.4 g, 8.1 mmol) to a mixture solvent of toluene (900 mL), EtOH (240 mL), and purified water (240 mL), the mixture was stirred under reflux for 1 day. After completing the reaction, the mixture was cooled to room temperature, and then extracted with distilled water and EA. Then, the organic layer was distilled under reduced pressure, and then separated with a column with MC/hexane to obtain compound C-7-1 (42 g, 92 %).
References:
WO2013/122402,2013,A1 Location in patent:Paragraph 196-198
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