Yield:1261216-27-6 70.4%

Reaction Conditions:

with N-Bromosuccinimide in acetonitrile at 30; for 2 h;

Steps:

11.1 (1) Preparation of 4-bromo-2-fluoro-6-methoxyaniline

2-Fluoro-6-methoxyaniline (5 g, 35.50 mmol) and N-bromosuccinimide (7 g, 39.1 mmol) were dissolved in 100 mL of acetonitrile and reacted at 30 ° C for 2 h. After the reaction is completed, the reaction solution is concentrated, and the residue is subjected to silica gel column chromatography.(Dichloromethane:methanol = 10:1) gave product (5.5 g, yield 70.4%).

References:

CN109265471,2019,A Location in patent:Paragraph 0537; 0539; 0540; 0541