4-BROMO-2-CHLORO-6-METHYLPHENOL synthesis
- Product Name:4-BROMO-2-CHLORO-6-METHYLPHENOL
- CAS Number:7530-27-0
- Molecular formula:C7H6BrClO
- Molecular Weight:221.48
87-64-9
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$9.00/1g
7530-27-0
91 suppliers
$6.00/1g
Yield:7530-27-0 52%
Reaction Conditions:
with N-Bromosuccinimide;acetic acid at 20; for 12 h;
Steps:
5.2 Step 2: 2-Chloro-4-bromo-6-methylphenol (35)
To a solution of 2-chloro-6- methylphenol 34 (5 g, 35 mmol) in AcOH (70 mL) was added NBS (6.2 g, 35 mmol). The solution was stirred at RT for 12 h. AcOH was removed under reduced pressure. The residue was diluted with EtOAc, washed with saturated Na2C03 solution and dried over Na2S04. Removal of the solvents gave compound 35 (4 g, 52%) which was used in the next step without further purification.
References:
WO2017/4609,2017,A1 Location in patent:Paragraph 0219
2362-12-1
188 suppliers
$5.00/1g
7530-27-0
91 suppliers
$6.00/1g