ChemicalBook CAS DataBase List 4-BROMO-1-TRITYL-1H-IMIDAZOLE

4-BROMO-1-TRITYL-1H-IMIDAZOLE synthesis

3synthesis methods

Product Name:4-BROMO-1-TRITYL-1H-IMIDAZOLE
CAS Number:87941-55-7
Molecular formula:C22H17BrN2
Molecular Weight:389.29

2302-25-2 Synthesis

2302-25-2
244 suppliers
$6.00/1g

76-83-5 Synthesis

76-83-5
703 suppliers
$6.00/25g

87941-55-7
81 suppliers
$69.00/1g

Yield:87941-55-7 72%

Reaction Conditions:

with triethylamine in tetrahydrofuran;dichloromethane at 20; for 1 h;

Steps:

1.4 (4) Synthesis of 4-bromo-1-trityl-1H-imidazole (Intermediate 7)
To a single-necked flask was added 4-bromoimidazole (30 g, 205 mmol)Dichloromethane: tetrahydrofuran = 1: 1,And triphenylchloromethane (62 g, 226 mmol)Triethylamine (29 ml) was added with stirring at room temperature,Continue stirring for 1 h, add water and 1N hydrochloric acid,Adding methylene chloride extraction,The organic layers were combined and dried over anhydrous sodium sulfate,Spin dry dichloromethane to give compound 7 (61g, 72% yield).

References:

Hinova Pharmaceuticals Inc.;Fan, Lei;Chen, Ke;Li, Xinghai;Chen, Yuanwei CN106256830, 2016, A Location in patent:Paragraph 0044; 0045; 0055; 0056; 0057

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