ChemicalBook CAS DataBase List 4-acetyl-2-methylbenzoic acid

4-acetyl-2-methylbenzoic acid synthesis

9synthesis methods

Product Name:4-acetyl-2-methylbenzoic acid
CAS Number:55860-35-0
Molecular formula:C10H10O3
Molecular Weight:178.18

4-acetyl-2-methylbenzoic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. Synthesis of 4-acetyl-2-methylbenzoic acid is: 4-bromo-2-methylbenzoic acid and n-butyl vinyl ether was refluxed for 5 hours at 80°C, palladium acetate as catalyst, yield 95%.

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55860-35-0
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Yield:55860-35-0 84%

Reaction Conditions:

with trifluoroacetic acid at 60; for 12 h;Reagent/catalyst;Temperature;

Steps:

1-3 Preparation of 2-methyl-4-acetylbenzoic acid

1 mmol (1.59 g) of 3-methyl-4-cyanoacetophenone was added to a 100 mL flask.Add 10 ml of trifluoroacetic acid, react at 60 ° C for 12 hours, detect by TLC, after the reaction is completed,Add 10% sodium carbonate melt and adjust to pH 2,It was extracted 3 times with ethyl acetate, and the organic phases were combined, dried and evaporated.Obtained 1.50 g of a beige solid.The yield was 84%.

References:

CN109553528,2019,A Location in patent:Paragraph 0012; 0014; 0016; 0018; 0020; 0022