4,6-DIFLUORO-3-IODOINDAZOLE synthesis
- Product Name:4,6-DIFLUORO-3-IODOINDAZOLE
- CAS Number:887567-79-5
- Molecular formula:C7H3F2IN2
- Molecular Weight:280.01
885520-26-3
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887567-79-5
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$57.00/100mg
Yield:887567-79-5 2.18 g
Reaction Conditions:
with iodine;potassium hydroxide in N,N-dimethyl-formamide at 20; for 2 h;
Steps:
101.1 Step 14 ,6 -Difluoro -3 -iodo - 1 H-indazo le
Example 101.2-(4,6-Difiuoro-l-methyl-lH-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylisopropylamideStep 14 ,6 -Difluoro -3 -iodo - 1 H-indazo leTo a solution of 4,6-difluoro-l H-indazo le (1.16 g, 7.53 mmol) in DMF (60 ml) at room temperature was added potassium hydroxide ( 1.27 g, 22.6 mmol) and iodine (2.87 g, 11.3 mmol). The maroon reaction mixture was stirred at room temperature for 2 h then quenched with 10% aqueous Na2S203 and diluted with water. The mixture was extracted with EtOAc (2x). The combined organics were washed with water, sat LiCl, and sat NaCl, then dried over MgSC^ and concentrated to afford 2.18 g of 4,6-difluoro-3-iodo-l H-indazo le as a light brown solid.
References:
WO2013/30138,2013,A1 Location in patent:Page/Page column 262; 263
58551-83-0
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887567-79-5
27 suppliers
$57.00/100mg