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7038-63-3

(4,6-DICHLORO-PYRIMIDIN-2-YL)-DIETHYLAMINE synthesis

2synthesis methods
-

Yield:78418-15-2 62%

Reaction Conditions:

with triethylamine in ethanol at 0; for 0.5 h;

Steps:

1.1

Example 1. Synthesis of Compound 30. The synthesis of the 30 consists of 4 steps. The following scheme depicts the synthetic route: EPO H STEP-I: Synthesis of (2,6-Dichloro-ρyrimidin-4-yl)-diethyl-amine L. To a stirred solution of 2.Og (10.90mmols) of 2,4,6-trichloropyrimidine in 25mL of anhydrous ethanol at 0 0C, was added drop wise a solution 0.79g (10.90mmols) of diethylamine in 5mL of ethanol. This was followed by the addition of 2.3mL (16.35mmols) of triethylamine and the mixture was stirred for further 30min. The mixture was then concentrated and 25mL OfCH2Cl2 and 25mL of water were added. The organic layer was separated and the aqueous layer was extracted by additional amount of dichloromethane (2 x 1OmL) and the extracts were combined, dried over anhydrousNa2SO4 and concentrated. Column chromatography on silica gel afforded 1.48g (62%) of L as colorless solid

References:

WO2006/53109,2006,A1 Location in patent:Page/Page column 99-100

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