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42414-28-8

4,6,8-trimethylquinolin-2-ol synthesis

1synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran; water / 16 h / Reflux
2.1: triethylamine / dichloromethane / 25 °C / Inert atmosphere
2.2: 25 °C
3.1: (4-fluorophenyl)-λ3-iodanediyl diacetate / chloroform / 24 h / 25 °C / Sealed tube

References:

Fan, Huaqiang;Pan, Peng;Zhang, Yongqiang;Wang, Wei [Organic Letters,2018,vol. 20,# 24,p. 7929 - 7932]