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ChemicalBook CAS DataBase List 4-(5-METHYL-2-THIENYL)-4-OXOBUTYRIC ACID
22988-52-9

4-(5-METHYL-2-THIENYL)-4-OXOBUTYRIC ACID synthesis

7synthesis methods
-

Yield:22988-52-9 95%

Reaction Conditions:

with aluminum (III) chloride in dichloromethane at 0 - 50; for 3 h;

Steps:

15.1 Step 1.

AlCl3 (13.3 g, 100.0 mmol) was added into a solution of 2-methylthiophene (4.9 g, 50 mmol) and tetrahydrofuran-2,5-dione (6.0 g, 60 mmol) in DCM (150 mL) at 0oC. After addition, the mixture was stirred at 50oC for 3 hours. Then, the mixture was diluted with H2O (150 mL). The organic phase was washed with H2O and brine, dried over Na2SO4, filtered and concentrated to yield 4-(5-methyl-2-thienyl)-4-oxo-butanoic acid as a yellow solid (9.4 g, 95% yield). LCMS purity: 98%; MS: m/z (ES+) = 199 (M+H+).

References:

WO2021/113809,2021,A1 Location in patent:Page/Page column 94-95

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