ChemicalBook CAS DataBase List 4,5-Dihydro-6-methylpyridazin-3(2H)-one

4,5-Dihydro-6-methylpyridazin-3(2H)-one synthesis

10synthesis methods

Product Name:4,5-Dihydro-6-methylpyridazin-3(2H)-one
CAS Number:5157-08-4
Molecular formula:C5H8N2O
Molecular Weight:112.13

123-76-2 Synthesis

123-76-2
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$5.00/25g

5157-08-4
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$11.00/1g

Yield:5157-08-4 99%

Reaction Conditions:

with hydrazine hydrazine hydrate at 100; for 0.666667 h;Temperature;

Steps:

1-10

Add 4 mL of levulinic acid and 1 mL of 80% hydrazine hydrate solution into a 10 mL glass tube reactor, seal the reactor, then heat the glass tube reactor to 100 °C, and react at 100 °C for 40 min to obtain a light yellow transparent solution (see figure 1).After cooling, the glass tube reactor was opened, the obtained glass tube reactor product was dissolved in methanol solution, and two internal standards (dimethyl succinate and anisole) were added to carry out gas chromatography-mass spectrometry (GC-MS) Analytical (qualitative) and gas chromatography-hydrogen ion flame detector (GC-FID) analysis (quantitative).GC-MS analysis was performed, and the methanol solution contained the main product 4,5-dihydro-6-methylpyridazin-3(2H)-one and unreacted levulinic acid (see Figure 2);Quantitative analysis by GC-FID (see Figure 3), the product contained 2.05g of 4,5-dihydro-6-methylpyridazin-3(2H))-one;The selectivity for 4,5-dihydro-6-methylpyridazin-3(2H)-one was 99% based on the hydrazine hydrate reaction.

References:

CN115057820,2022,A Location in patent:Paragraph 0021-0030

624-45-3 Synthesis