4-(5-AMINO-3-TERT-BUTYL-PYRAZOL-1-YL)-BENZOIC ACID synthesis
- Product Name:4-(5-AMINO-3-TERT-BUTYL-PYRAZOL-1-YL)-BENZOIC ACID
- CAS Number:869663-56-9
- Molecular formula:C14H17N3O2
- Molecular Weight:259.3
59997-51-2
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869663-56-9
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Yield:869663-56-9 99%
Reaction Conditions:
with acetic acid in tetrahydrofuran;ethanol; for 16 h;Heating / reflux;
Steps:
6
A mixture of 4,4-dimethyl-3-oxo-pentanenitrile (4.52 g, 36.15 mmol), 4- hydrazinobenzoic acid (5.00 g, 32.86 mmol), and acetic acid (2 mL) in EtOH/THF (1:1) was refluxed for 16 h. After cooling, the solvent was concentrated under reduced pressure, and the crude was re-dissolved in EtOAc. The organic layer was
References:
WO2007/64872,2007,A2 Location in patent:Page/Page column 75-76