ChemicalBook CAS DataBase List 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE

4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE synthesis

9synthesis methods

Product Name:4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE
CAS Number:2933-29-1
Molecular formula:C7H10N2S
Molecular Weight:154.23

108-94-1 Synthesis

108-94-1
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4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE

2933-29-1
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$11.00/100mg

Yield: 80%

Reaction Conditions:

with iodine in ethanol for 3 h;Reflux;

Steps:

2.3. General procedure for the preparation of 2-aminothiazole derivatives
General procedure: A mixture of the acetophenone (2 mmol), thiourea (3 mmol) and iodine (2 mmol), in the presence of 0.03 g nanochitosan was refluxed in EtOH.
The progress of the reaction was monitored by TLC (petroleum ether-ethyl acetate 4:1).
After completion of the reaction, the catalyst was separated by simple filtration.
After evaporation of solvent, the crude product was dissolved in boiling water, extracted with ether (3 * 30 mL), and adjusted to pH = 8 with the amount of ammonia to give the solid products.
The solid was recrystallized with ethanol-water to give pure 2-aminothiazole.

References:

Safari, Javad;Abedi-Jazini, Zahra;Zarnegar, Zohre;Sadeghi, Masoud [Catalysis Communications,2016,vol. 77,p. 108 - 112]