4,5,6,7-Tetrahydro-1-benzothiophene-2-carbaldehyde synthesis

2synthesis methods

Product Name:4,5,6,7-Tetrahydro-1-benzothiophene-2-carbaldehyde
CAS Number:57021-53-1
Molecular formula:C9H10OS
Molecular Weight:166.24

N-methoxy-N-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide

1346672-52-3
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4,5,6,7-Tetrahydro-1-benzothiophene-2-carbaldehyde

57021-53-1
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$66.00/250mg

Yield:57021-53-1 54%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at -55 - 25; for 3 h;

Steps:

44.2 Step 2

A suspension of compound 56b (5 g, 23.6mmol) in THF (150 mL) was added LiAlH₄ (0.89 g, 22mmol) under -55 °C. After that the temperature was rebound to 25 °C for 3 hours. The mixture was pouring to water, extracted with ethyl acetate. The organic layer was washed with water, brine and dried over sodium sulfate, concentrated in vacuo to provide compound 56c (2 g, 54% yield). LC/MS: Anal. Calcd. For [M+H]⁺ C9H10OS: 167.05; found 167.0

References:

WO2014/110688,2014,A1 Location in patent:Page/Page column 118

40133-07-1 Synthesis

4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID

40133-07-1
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$18.00/100mg

57021-53-1
13 suppliers
$66.00/250mg

References