4-(4-Propylcyclohexyl)cyclohexanone synthesis
- Product Name:4-(4-Propylcyclohexyl)cyclohexanone
- CAS Number:87625-09-0
- Molecular formula:C15H26O
- Molecular Weight:222.37
87144-93-2
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87625-09-0
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Yield:87625-09-0 89%
Reaction Conditions:
Stage #1: 4-(4-propylcyclohexyl)-cyclohexanolwith 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxyl anion in 1,2-dichloro-ethane at 5; for 0.25 h;
Stage #2: with trichloroisocyanuric acid in 1,2-dichloro-ethane; for 8 h;
Steps:
3.2
(2) Add 22.4g 4-(4-propylcyclohexyl)cyclohexanol (0.1mol), 200mL dichloroethane, 1.4g catalyst (shown in formula 1, 8mmol), stir for 15min at 5, slowly add 18.6g TCCA (0.08mol) in batches, keep the reaction for 8h after the addition is complete, then filter, the filtrate is quenched with sodium thiosulfate, and the organic phase is washed with saturated sodium carbonate , Drying and concentrating to obtain 19.8 g of white solid 4-(4-propylcyclohexyl)cyclohexanone with a yield of 89.0%.
References:
CN112811995,2021,A Location in patent:Paragraph 0052; 0054-0055
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