4-(4-BROMO-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE synthesis
- Product Name:4-(4-BROMO-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE
- CAS Number:91347-99-8
- Molecular formula:C11H12BrN
- Molecular Weight:238.12
273727-44-9
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Yield:91347-99-8 88 %
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20;Inert atmosphere;
Steps:
9.2 Step 2: 4-(4-bromophenyl) - 1, 2, 3, 6-tetrahydropyridine
Trifluoroacetic acid (1.250 ml, 16.32 mmol)was added to solution of tert-butyl4-(4-bromophenyl)-3,6-dihydropyridine-1(2H)-carboxylate (1.38 g, 4.08 mmol) in CH2CI2 (10ml) under argon at RT. The reaction mixture was stirred at RT for 1 h. Complete conversion to the desired product was observed by LCMS. The mixture was concentrated and the residue was dissolved in MeOH (20 mL), passed through a 5 G porapak cation exchange cartridge and the eluant was removed to afford the product as a beige solid (854 mg, 88%). LCMS: [M + H]+ = 240.36.
References:
WO2022/226665,2022,A1 Location in patent:Paragraph 0338; 0339
163209-96-9
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79099-07-3
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106-37-6
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589-87-7
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91347-99-8
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