4(3H)-Quinazolinone, 6-(trifluoromethoxy)- synthesis
1synthesis methods
- Product Name:4(3H)-Quinazolinone, 6-(trifluoromethoxy)-
- CAS Number:179246-09-4
- Molecular formula:C9H5F3N2O2
- Molecular Weight:230.14
Yield:179246-09-4 82%
Reaction Conditions:
in 2-ethoxy-ethanol; for 2 h;Heating / reflux;
Steps:
D4.4
A mixture of 2-amino-5-trifluoromethoxy-benzoic acid, HCl salt (1.52 g, 5.91 mMol), and formamidine acetate (1.84 g, 17.73 mMol) in 2-ethoxyethanol (20 mL) was heated at reflux for 2 hours. Analysis by LC/MS showed that the reaction was complete, so the mixture was concentrated in-vacuo, and the residue was purified over silica gel, eluting with 50% ethyl acetate/heptane-100% ethyl acetate, to yield 1.1 g of white solids as product. MS (ES+)=231 (M+H)+. Yield=82%.
References:
US2005/54626,2005,A1 Location in patent:Page/Page column 39