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145485-43-4

4-(3-TrifluoroMethyl-phenyl)-butyric acid synthesis

7synthesis methods
-

Yield:145485-43-4 94%

Reaction Conditions:

with propyl alcohol;bis(1,5-cyclooctadiene)nickel (0);potassium-t-butoxide;4,4-dibenzyl-2-(pyridin-2-yl)-4,5-dihydrooxazole at 60;Sealed tube;regioselective reaction;

References:

Deng, Ruohan;Engle, Keary M.;Fu, Yue;Gao, Yang;Li, Zi-Qi;Liu, Peng;Tran, Van T. [Angewandte Chemie - International Edition,2020,vol. 59,# 51,p. 23306 - 23312][Angew. Chem.,2020,vol. 132,# 51,p. 23506 - 23512,7] Location in patent:supporting information