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35198-42-6

4-(2-OxiranylMethoxy)benzeneacetonitrile synthesis

2synthesis methods
14191-95-8 Synthesis
4-Hydroxybenzyl cyanide

14191-95-8
405 suppliers
$6.00/5g

-

Yield:35198-42-6 82%

Reaction Conditions:

Stage #1: 4-cyanomethylphenol;epichlorohydrinwith tetrabutylammomium bromide at 68; for 6 h;
Stage #2: with water;sodium hydroxide in acetone; for 3 h;

Steps:

2.2 (2) Preparation of 4- (2-oxiranemethoxy) phenylacetonitrile

Add p-hydroxyphenylethyl cyanide (0.01 mol, 1.33 g) and epichlorohydrin (0.10 mol, 9.25 g) to a 100 mL single-necked bottle with magnets, heat up to 68 ° C, and add tetrabutyl dichloromethane after the raw materials are dissolved. Ammonium bromide (0.001 mol, 0.322 g). After 6 hours of reaction, a 15% sodium hydroxide aqueous solution (0.02 mol, 0.80 g) was added. After 3 hours of reaction, the reaction was stopped.60 mL of toluene was added and stirred for 10 minutes. The lower aqueous layer was discharged with a separatory funnel, and the organic phase was washed twice with water. The organic phase layer was collected and the solvent was spin-dried to obtain a crude product. The crude product was a mixed solvent of dichloromethane and petroleum ether (V : V = 3: 1) was used as the eluent for column separation to obtain 1.54 g of pure product with a yield of 82%.

References:

CN110407772,2019,A Location in patent:Paragraph 0053; 0063; 0067-0068