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ChemicalBook CAS DataBase List 4-(2-chloro-phenyl)-butyric acid
68449-31-0

4-(2-chloro-phenyl)-butyric acid synthesis

5synthesis methods
3900-89-8 Synthesis
2-Chlorophenylboronic acid

3900-89-8
385 suppliers
$6.00/1g

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: potassium carbonate; palladium diacetate / toluene / 3 h / 90 °C / Inert atmosphere
2: formic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)] / tetrahydrofuran / 100 °C / Inert atmosphere; Sealed tube

References:

Wu, Fu-Peng;Li, Da;Peng, Jin-Bao;Wu, Xiao-Feng [Organic Letters,2019,vol. 21,# 14,p. 5699 - 5703]