ChemicalBook CAS DataBase List 4-(1-NAPHTHYL)-3-THIOSEMICARBAZIDE

4-(1-NAPHTHYL)-3-THIOSEMICARBAZIDE synthesis

7synthesis methods

Product Name:4-(1-NAPHTHYL)-3-THIOSEMICARBAZIDE
CAS Number:42135-78-4
Molecular formula:C11H11N3S
Molecular Weight:217.29

551-06-4
117 suppliers
$27.00/1g

42135-78-4
33 suppliers
inquiry

Yield:42135-78-4 98%

Reaction Conditions:

with hydrazine hydrate monohydrate in diethyl ether at 20; for 0.5 h;

Steps:

4-(1-naphthyl)-3-thiosemicarbazide, NfTs.

To a solution of 2.51 g(13.6 mmol) of 1-naphthylisothiocyanate in 20 mL of diethyl ether wasadded 1.0 mL (20.6 mmol) of hydrazine monohydrate. The mixture wasstirred for 30 min at room temperature. The white solid was filtered off,washed thoroughly with diethyl ether and vacuum-dried (2.88 g, 98%).δH(300 MHz, DMSO-d6, Me4Si) 9.23 (1H, s, H6A), 7.99-7.51 (7H, m, H6-H13), 7.49 (1H, s, H5), 3.35 (2H, s, NH2).

References:

González-García, Cristina;García-Pascual, Cristina;Burón, Rodrigo;Calatayud, David G.;Perles, Josefina;Mendiola, M. Antonia;López-Torres, Elena [Polyhedron,2022,vol. 223,art. no. 115945]