4-(1,3,4-OXADIAZOL-2-YL)ANILINE synthesis
- Product Name:4-(1,3,4-OXADIAZOL-2-YL)ANILINE
- CAS Number:35219-13-7
- Molecular formula:C8H7N3O
- Molecular Weight:161.16
1895-39-2
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5351-17-7
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35219-13-7
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Yield:35219-13-7 81%
Reaction Conditions:
with potassium phosphate in acetonitrile at 100; for 1 h;Sealed tube;Inert atmosphere;
Steps:
2. General procedure for the synthesis of 3
General procedure: CH3CN (2 mL) was added to a mixture of ClCF2COONa 2a (0.3 mmol, 1.5 equiv) and hydrazides 1 (0.2 mmol, 1 equiv) in the presence of K3PO4 (0.3 mmol, 1.5 equiv). Then the sealed tube was stirred at 100 °C under N2 for 1 h. Upon completion of the reaction, the solvent was evaporated under reduced pressure and the residue was purified by flash column chromatograph (silica gel, petroleum ether:EtOAc = 2:1, v/v) to give the desired product 3.
References:
Wang, Ya;Mu, Shiqiang;Li, Xin;Song, Qiuling [Chinese Chemical Letters,2022,vol. 33,# 3,p. 1511 - 1514] Location in patent:supporting information
4291-13-8
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35219-13-7
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5565-72-0
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35219-13-7
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5378-35-8
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636-97-5
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35219-13-7
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