2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy- synthesis

6synthesis methods

Product Name:2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy-
CAS Number:37682-06-7
Molecular formula:C11H13NO2
Molecular Weight:191.23

85175-85-5 Synthesis

8-METHOXY-1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE

85175-85-5
28 suppliers
$65.00/10mg

2H-3-Benzazepin-2-one, 1,3,4,5-tetrahydro-8-Methoxy-

37682-06-7
26 suppliers
$284.57/250mg

Yield:37682-06-7 96%

Reaction Conditions:

with 10% Pd/C;hydrogen in acetic acid; under 3102.97 Torr; for 8 h;

Steps:

(d). 8-Methoxy-1,3,4,5-tetrahydrobenzo[d]azepine-2-one (3)

A solution of compound 2 (6.0 g, 31.7 mmol) in AcOH (100 mL) was hydrogenated over 10% Pd/C (600 mg) at 60 psi for 8 h. The catalyst was filtered off through a layer of Celite, and the filtrate was concentrated in vacuo. The crude product was triturated with Et₂O to afford 3 (5.83 g, 96%) as a pale pink solid

References:

Wang, Min;Gao, Mingzhang;Steele, Brandon L.;Glick-Wilson, Barbara E.;Brown-Proctor, Clive;Shekhar, Anantha;Hutchins, Gary D.;Zheng, Qi-Huang [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 14,p. 4713 - 4718] Location in patent:experimental part

4133-34-0 Synthesis